Our understanding of the role of alternatively spliced (AS) proteins in macrophage-driven immunopathologies and our ability to selectively target these proteins with small molecules remain limited. The Vinogradova lab aims to bridge this gap in understanding by introducing advanced analytical pipelines which integrate RNA sequencing outputs with state-of-the-art functional proteomic platforms for identification, functional validation, and targeting of the AS proteins.
A remarkable array of proteins—and the interplay between them—mediate the immune system’s response to external pathogens and internal damage, and determine the difference between health and disease. Vinogradova combines tools from chemistry, chemical proteomics, and cell biology to modulate and study the functions of immune proteins. The work is illuminating innovative ways to treat immune-related disorders.
